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| Jacobs,Clifford; Pearce,Brendon; Du Plessis,Mornè; Hoosain,Nisreen; Benjeddou,Mongi. |
| Human organic cation transporter 1 is primarily expressed in hepatocytes and mediates the electrogenic transport of various endogenous and exogenous compounds, including clinically important drugs. Genetic polymorphisms in the gene coding for human organic cation transporter 1, SLC22A1, are increasingly being recognized as a possible mechanism explaining the variable response to clinical drugs, which are substrates for this transporter. The genotypic and allelic distributions of 19 nonsynonymous and one intronic SLC22A1 single nucleotide polymorphisms were determined in 148 healthy Xhosa participants from South Africa, using a SNAPshot® multiplex assay. In addition, haplotype structure for SLC22A1 was inferred from the genotypic data. The minor allele... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polymorphism; Haplotype; Population genetic structure; Genotyping; Genetic variability. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000300006 |
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| De Noia, Michele; Telesca, Luca; Vendrami, David L. J.; Gokalp, Hatice K.; Charrier, Gregory; Harper, Elizabeth M.; Hoffman, Joseph I.. |
| The soft-shell clam Mya arenaria is one of the most ancient invaders of European coasts and is present in many coastal ecosystems, yet little is known about its genetic structure in Europe. We collected 266 samples spanning a latitudinal cline from the Mediterranean to the North Sea and genotyped them at 12 microsatellite loci. In parallel, geometric morphometric analysis of shell outlines was used to test for associations between shell shape, latitude and genotype, and for a selection of shells we measured the thickness and organic content of the granular prismatic (PR), the crossed-lamellar (CL) and the complex crossed-lamellar (CCL) layers. Strong population structure was detected, with Bayesian cluster analysis identifying four groups located in the... |
| Tipo: Text |
Palavras-chave: Mya arenaria; Soft-shell clam; Microsatellite; Population genetic structure; Phenotypic plasticity; Shell morphometrics. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00614/72600/71593.pdf |
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| Djuikwo-teukeng, Felicite Flore; Simo, Alain Kouam; Allienne, Jean-francois; Rey, Olivier; Ngapagna, Arouna Njayou; Tchuem-tchuente, Louis Albert; Boissier, Jerome. |
| BackgroundSchistosomiasis is neglected tropical parasitic disease affecting both humans and animals. Due to the human health impact, population genetic studies have focused on the three main human-infecting schistosome species: Schistosoma mansoni, S. haematobium and S. japonicum. Here we present novel data on the population genetic structure of Schistosoma bovis, a highly widespread and prevalent schistosome infecting ruminants, and therefore of veterinary importance.MethodsAdult S. bovis were sampled in the two main abattoirs of Cameroon (Yaounde and Douala). Twenty-two cows originating from four distinct localities were sampled and a total of 218 parasites were recovered. All parasites were genotyped using a panel of 14 microsatellite markers and a... |
| Tipo: Text |
Palavras-chave: Schistosoma bovis; Barcoding; Population genetic structure. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00481/59267/62448.pdf |
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